ZOMETA Formulations

ZOMETA is available in 3 formulations¹*

Convenient, ready-to-use formulation: 4 mg/100 mL solution for infusion¹

ZOMETA 4 mg/100 mL solution for infusion is supplied in packs containing 1 bottle as a unit pack or in multipacks comprising 4 or 5 packs, each containing 1 bottle.¹

• ZOMETA 4 mg/100 mL is ready to use¹
  • Do not dilute or mix with other infusion solutions
• Administer as a single intravenous solution in a separate infusion line¹

Learn how to adjust the dose to protect patients’ renal health.

4 mg/5 mL concentrate¹

ZOMETA 4 mg/5 mL concentrate for solution for infusion is supplied as packs containing 1, 4, or 10 vials.¹

• Withdraw 5.0 mL (or a lower volume, if required) from vial¹
• Further dilute with 100 mL of calcium-free infusion solution (0.9% weight per volume [w/v] sodium chloride solution or 5% w/v glucose solution)¹
• If ZOMETA is not used immediately, the total time between dilution, storage in a refrigerator at 2°C–8°C, and end of administration must not exceed 24 hours¹
• The solution must be allowed to reach room temperature before administration¹

4 mg powder and solvent¹

ZOMETA 4 mg powder for solution for infusion is supplied as packs containing 1, 4, or 10 6-mL vials containing 4 mg zoledronic acid powder and 1, 4, or 10 5-mL ampoules of water for injections, respectively.¹

• The powder must be dissolved completely in the vial using 5 mL water for injections from the ampoule supplied¹
• Further dilute the required amount with 100 mL of calcium-free infusion solution (0.9% w/v sodium chloride solution or 5% w/v glucose solution)¹
• If ZOMETA is not used immediately, the total time between reconstitution, dilution, storage in a refrigerator at 2°C–8°C, and end of administration must not exceed 24 hours¹
• The solution must be allowed to reach room temperature before administration¹

*Note that not all the formulations are widely available in all countries.